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Updated: Sep 22, 2025
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Cardiovascular Diseases and Periodontitis.
Peter Riis Hansen1,2, Palle Holmstrup3
1Department of Cardiology, Herlev-Gentofte University Hospital, The Capital Region of Denmark, Hellerup, Denmark. peter.riis.hansen@regionh.dk.
Advances in Experimental Medicine and Biology
|May 25, 2022
Summary
Periodontitis, a gum disease, is linked to cardiovascular disease (CVD) through systemic inflammation. Treating periodontitis may reduce this inflammation and lower the risk of CVD.
Area of Science:
- Periodontology
- Cardiovascular Medicine
- Immunology
Background:
- Periodontitis is a common chronic inflammatory disease affecting tooth support structures.
- It is associated with systemic comorbidities like cardiovascular disease (CVD), diabetes, and rheumatoid arthritis.
- These conditions share inflammatory pathways, suggesting a causal link driven by low-grade inflammation (LGI).
Purpose of the Study:
- To review translational evidence linking periodontitis to CVD.
- To explore the role of systemic low-grade inflammation (LGI) in this association.
- To evaluate the impact of periodontitis treatment on CVD risk factors.
Main Methods:
- Review of experimental studies, observational data, and interventional trials.
- Analysis of recent randomized studies on periodontitis treatment and blood pressure.
- Examination of data on anti-inflammatory therapy in CVD patients.
Main Results:
- Intensive periodontitis treatment reduced blood pressure and systemic inflammatory markers in hypertensive patients.
- Targeted anti-inflammatory therapy reduced CVD events in patients with established CVD and LGI.
- Residual inflammatory risk is an independent risk factor for atherothrombotic CVD.
Conclusions:
- Periodontitis is a significant risk factor for CVD, mediated by LGI.
- Treatment of periodontitis likely contributes to reducing residual inflammatory risk.
- Addressing periodontitis may be a crucial strategy for CVD prevention.
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