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Periodontal Cell Therapy: A Systematic Review and Meta-analysis
Antoine Dubuc1, Valérie Planat-Bénard2, Mathieu Marty1
1Dental Faculty, Paul Sabatier University, Toulouse Hospital (Hôpitaux de Toulouse) University, and Toulouse Institute of Oral Medicine, Toulouse, France.
Advances in Experimental Medicine and Biology
|May 25, 2022
Summary
Mesenchymal stromal cells (MSCs) therapy shows promise for periodontal regeneration in animal studies. Further research is needed to refine protocols for human application, focusing on the disease
Area of Science:
- Regenerative Medicine
- Periodontology
- Stem Cell Therapy
Background:
- Periodontitis is a chronic inflammatory disease causing tooth loss.
- Current therapies focus on repair, not disease causes, with disappointing results.
- Periodontal mesenchymal stromal cells (MSCs) offer immunomodulatory and trophic properties for tissue regeneration.
Purpose of the Study:
- To evaluate the efficacy of mesenchymal stromal cells (MSCs) therapy for periodontal regeneration.
- To analyze results from experimental studies investigating MSCs in periodontal disease models.
Main Methods:
- A meta-analysis of 84 animal and 3 human studies.
- Searches conducted on PubMed and ICTRP databases.
Main Results:
- MSCs grafting enhances periodontal regeneration across various tissue origins.
- Optimal efficacy requires suitable defect morphology and natural origin cell carriers.
- Methodological biases and limited human trials hinder clinical translation.
Conclusions:
- MSCs therapy demonstrates therapeutic benefits in animal models of periodontal disease.
- Accurate, translatable protocols are crucial for human application.
- Treatment should address the whole pathology, not just tissue restitution.
Keywords:
Cell carrierCell therapyMesenchymal stromal cellMeta-analysisPeriodontal diseasePeriodontitisTissue engineering
