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Updated: Sep 8, 2025
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A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
Published on: October 6, 2018
8.2K
Narrative engineering of the liver.
Inkyu S Lee1, Takanori Takebe2
1Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Current Opinion in Genetics & Development
|June 14, 2022
Summary
Liver organoids, derived from stem cells, offer promising biomedical applications. Narrative engineering aims to control their development for improved disease modeling and drug testing.
Area of Science:
- Biomedical Engineering
- Developmental Biology
- Regenerative Medicine
Background:
- Liver organoids are 3D structures derived from stem cells that mimic liver development and function in vitro.
- They hold potential for disease modeling, drug testing, and therapeutic applications.
- Current challenges include controlling their cellular composition, structure, maturity, and scalability.
Purpose of the Study:
- To discuss advancements in liver organoid technology.
- To explore the concept of 'narrative engineering' for organoid development.
- To bridge the understanding of hepatogenesis with bioengineering approaches.
Main Methods:
- Reviewing current liver organoid technologies.
- Applying the 'narrative engineering' framework.
- Integrating knowledge of hepatogenesis with bioengineering principles.
Main Results:
- Liver organoid technology is advancing rapidly.
- 'Narrative engineering' provides a framework for controlled organoid development.
- Synergy between developmental biology and bioengineering is key.
Conclusions:
- Controlled development of liver organoids is crucial for their applications.
- Narrative engineering offers a promising approach to achieve this control.
- Further integration of biological insights and engineering strategies will advance the field.
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