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What Have We Learned in the Last 20 Years About CRT Non-Responders?
Peregrine G Green1, Neil Herring2, Timothy R Betts3
1Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Level 0 John Radcliffe Hospital, Oxford, OX3 9DU, UK; Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.
Abstract:
Although cardiac resynchronization therapy (CRT) has become well established in the treatment of heart failure, the management of patients who do not respond after CRT remains a key challenge. This review will summarize what we have learned about non-responders over the last 20 years and discuss methods for optimizing response, including the introduction of novel therapies.
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The transient response of the circuit is its temporary reaction to the sudden application of the DC source. This response is characterized by a current that exponentially decays to zero as time approaches infinity. During this transitional period, the inductor behaves like a short circuit, causing the source...