Simultaneous Biplane High Speed 1000 fps X-ray Angiography (HSAngio)

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Fluid Dynamics

Background:

• High-speed x-ray angiography (HSAngio) enables visualization of blood flow dynamics.
• Understanding blood flow in cerebral aneurysms is crucial for neurointerventional procedures.

Purpose of the Study:

• To present the first simultaneous orthogonal views of contrast injection in aneurysm models using biplane HSAngio.
• To evaluate the visualization capabilities of biplane HSAngio for complex cerebrovascular blood flow.

Main Methods:

• Utilized 3D-printed in-vitro models of internal carotid artery aneurysms connected to a flow loop.
• Injected iodine contrast agent at a controlled rate and acquired 1000 fps HSAngio sequences simultaneously on frontal and lateral planes.
• Synchronized contrast injection with biplane x-ray exposures and detector acquisitions.

Main Results:

• Frontal plane images effectively visualized flow streamlines in the parent artery (inflow: 28 cm/s, outflow: 24 cm/s).
• Lateral plane images provided superior visualization of vortices within the aneurysm dome (average velocity: 27 cm/s).

Conclusions:

• Biplane HSAngio imaging offers more accurate 3D blood flow representations in complex cerebrovascular pathologies than single-plane imaging.
• Simultaneous orthogonal views enhance the understanding of hemodynamics within aneurysm models.