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Structural Modifications and Strategies for Native Starch for Applications in Advanced Drug Delivery
Pankaj Bhatt1,2, Vipin Kumar2, Richa Goel1
1KIET Group of Institutions (KIET School of Pharmacy), Delhi NCR, Muradnagar, Ghaziabad, India.
Biomed Research International
|August 22, 2022
Summary
Modified starch offers a safe, biocompatible, and cost-effective alternative to synthetic pharmaceutical excipients. Structural modifications enhance starch properties for advanced drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biotechnology
Background:
- Synthetic pharmaceutical excipients can cause toxicity, inflammation, and autoimmune responses, lacking intrinsic bioactivity and biocompatibility.
- Native starch presents challenges as an excipient due to high digestibility, glycemic index, and suboptimal paste clarity and film-forming properties.
- There is a need for safer, more effective, and cost-efficient excipients in pharmaceutical formulations.
Purpose of the Study:
- To explore the potential of native starch as a pharmaceutical excipient.
- To investigate structural modifications of starch to overcome limitations for pharmaceutical applications.
- To develop modified starch for advanced and targeted drug delivery systems.
Main Methods:
- Physical modification of native starch.
- Chemical modification of native starch.
- Genetic and enzymatic modification of native starch.
- Analysis of altered molecular bonds, crystalline structure, and retrogradation.
Main Results:
- Modified starch exhibits reduced digestibility and glycemic index.
- Improvements in paste clarity, film-forming properties, and binding capabilities were observed.
- Structural alterations enhance starch's suitability for pharmaceutical use.
Conclusions:
- Structural modification of native starch yields a novel excipient with significant potential for the pharmaceutical industry.
- Modified starch offers a biocompatible, non-toxic, and cost-effective alternative to synthetic excipients.
- These modifications are applicable in advanced drug delivery systems, particularly for targeted delivery.
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