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Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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[Drug-drug interactions with Mexidol in patients with ischemic stroke: Analysis of data from randomized clinical trials].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
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[Multimodal antioxidant therapy in ischemic stroke: from MIR trial to bedside].

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Related Experiment Video

Updated: Aug 28, 2025

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

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COVID-19-Associated Stroke.

I A Shchukin1, M S Fidler1, I A Koltsov1

  • 1Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia.

Neuroscience and Behavioral Physiology
|September 19, 2022
PubMed
Summary
This summary is machine-generated.

The COVID-19 pandemic increases stroke risk by affecting angiotensin 2 receptors and causing inflammation. Antioxidant substances like Mexidol may improve outcomes for stroke patients with COVID-19.

Keywords:
Mexidolangiotensin receptorscoronavirus infectioncytokine stormischemic strokeoxidative stress

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Research

Background:

  • COVID-19 pandemic significantly impacts acute cerebrovascular accidents and mortality.
  • SARS-CoV-2 infection elevates risks for both ischemic and hemorrhagic stroke.
  • Pathogenesis involves angiotensin 2 receptor dysfunction, endothelial damage, hypercoagulation, and inflammation.

Purpose of the Study:

  • To explore the link between COVID-19 and stroke pathogenesis.
  • To evaluate potential therapeutic interventions for stroke in COVID-19 patients.
  • To assess the efficacy of antioxidant substances, specifically Mexidol.

Main Methods:

  • Review of existing clinical data and pathogenetic mechanisms.
  • Analysis of the impact of SARS-CoV-2 on cerebrovascular events.
  • Evaluation of antioxidant properties in mitigating stroke severity.

Main Results:

  • COVID-19-associated stroke involves complex systemic and cerebral ischemic mechanisms.
  • Current medication options for correcting systemic and local impairments are limited.
  • Antioxidant therapies show promise, with Mexidol demonstrating improved functional outcomes in ischemic stroke.

Conclusions:

  • Mexidol is a potentially effective treatment for patients experiencing stroke alongside COVID-19.
  • Further research into antioxidant interventions is warranted for managing cerebrovascular complications of COVID-19.
  • Understanding the pathogenetic links between SARS-CoV-2 and stroke is crucial for therapeutic development.