Assessment of three electrolyte-molecule electrostatic interaction models for 2D material based BioFETs

Area of Science:

• Nanotechnology
• Biophysics
• Materials Science

Background:

• Two-dimensional materials (2DMs) offer enhanced sensitivity for biosensors.
• Compact, CMOS-compatible biosensor design is a key goal.
• Accurate modeling of 2D Material-based Field-Effect Transistors (BioFETs) is needed.

Purpose of the Study:

• To develop a simulator for 2D material-based BioFETs.
• To analyze electrolyte-molecule interactions and charge screening effects.
• To evaluate different interaction models for BioFET simulations.

Main Methods:

• Developed a 2D material-based BioFET simulator.
• Incorporated complex electrolyte reactions and interaction models.
• Validated electrolyte simulations against experimental data and Debye-Hückel approximation.

Main Results:

• The simulator accurately models electrolyte behavior.
• Electrolyte charge screening significantly impacts device responsivity.
• Different interaction models yield varying results for BioFET simulations.

Conclusions:

• The study highlights the importance of accurate electrolyte modeling in BioFETs.
• Choosing appropriate interaction models is critical for reliable BioFET simulation.
• This work advances the understanding of biomolecule-device interactions in biosensing.