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Precision Medicine in Pediatric Cardiology

Sandra Kikano, Prince J Kannankeril

    Pediatric Annals
    |October 10, 2022
    PubMed

    Insights

    Precision medicine offers tailored treatments for diseases like congenital heart disease. Advances in genomics and pharmacogenetics improve risk prediction and drug efficacy in pediatric cardiology.

    Area of Science:

    • Cardiology
    • Genetics
    • Pharmacology

    Background:

    • Congenital heart disease (CHD) is a common birth defect with varied outcomes due to unknown causes.
    • Individual genetic and environmental factors are increasingly understood in pediatric cardiology.
    • Genomics and pharmacogenetics are vital for risk prediction and optimizing drug use in children.

    Purpose of the Study:

    • To review precision medicine in pediatric cardiology.
    • To highlight clinical effects of precision medicine in congenital heart disease patients.

    Main Methods:

    • Literature review of precision medicine advancements.
    • Analysis of genomic and pharmacogenetic data in pediatric cardiology.
    • Examination of clinical outcomes in congenital heart disease.

    Main Results:

    • Precision medicine strategies are emerging for individualized CHD treatment.
    • Genomic and environmental factors explain outcome variability in pediatric CHD.
    • Pharmacogenetics enhances drug safety and efficacy in pediatric populations.

    Conclusions:

    • Precision medicine holds promise for treating congenital heart disease.
    • Implementing precision medicine in healthcare presents challenges.
    • Genomic insights are crucial for advancing pediatric cardiology care.

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