Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

27
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
27
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

43
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
43
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

131
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
131
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

19
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
19
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

31
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
31

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Z_{3} Parafermion in the Double Charge Kondo Model.

Physical review letters·2023
Same author

Opportunity and Challenges of Interventional Cardiology.

Kathmandu University medical journal (KUMJ)·2022
Same author

Prevalence of White Coat Hypertension among the Patients Visiting in a Tertiary Care Center, Kathmandu, Nepal.

Kathmandu University medical journal (KUMJ)·2020
Same author

Prevalence of Diastolic Dysfunction in Type 2 Diabetes Mellitus.

Kathmandu University medical journal (KUMJ)·2018
Same author

Prevalence of Early Repolarization Patterns in Adults.

Kathmandu University medical journal (KUMJ)·2017
Same author

Unusual case of failure to thrive: Type III Bartter syndrome.

Journal of Nepal Health Research Council·2017
Same journal

Burkitt`s Lymphoma Presenting as Ileocolic Intussusception in a 8 year old boy.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Negative Pressure Pulmonary Edema Following Septorhinoplasty.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Corneal Deposits in a Jeweler: A case of ocular argyrosis.

Kathmandu University medical journal (KUMJ)·2026
Same journal

All on Four Implant Supported Denture -A zippy solution for complete edentulism.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Eye Care Professionals' Knowledge, Attitude and Practice (KAP) on Myopia Management Approach: A Global Review.

Kathmandu University medical journal (KUMJ)·2026
Same journal

Breastfeeding Self-efficacy and Postnatal Depressive Symptoms: A Cross-sectional Study among Postnatal Women.

Kathmandu University medical journal (KUMJ)·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.0K

Heart Failure: Past, Present, Future.

D B Karki1, T R Bhattarai2, A Rayamajhi3

  • 1Department of Cardiology, Kathmandu Medical College, Sinamangal, Kathmandu.

Kathmandu University Medical Journal (KUMJ)
|October 19, 2022
PubMed
Summary
This summary is machine-generated.

Heart failure affects millions globally, necessitating differentiation between HFrEF and HFpEF for effective treatment. Current therapies improve symptoms, but advanced stages require transplantation or mechanical support, with ongoing research promising better outcomes.

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.6K
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.6K

Related Experiment Videos

Last Updated: Aug 25, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.0K
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.6K
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.6K

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Heart failure is a global health crisis affecting 23 million people worldwide.
  • Distinguishing between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) is crucial for guiding treatment strategies.
  • Common etiologies include coronary artery disease, dilated cardiomyopathy, valvular heart disease, and hypertension.

Purpose of the Study:

  • To provide an overview of heart failure, its classifications, causes, and current management strategies.
  • To highlight the limitations of existing treatments and the challenges in managing end-stage heart failure, particularly in resource-limited settings.
  • To underscore the importance of ongoing research in developing more effective heart failure therapies.

Main Methods:

  • Review of existing literature on heart failure epidemiology, pathophysiology, and treatment modalities.
  • Analysis of pharmacological interventions and their impact on heart failure mortality.
  • Discussion of advanced treatment options including mechanical circulatory support and heart transplantation.

Main Results:

  • Several drug classes, including diuretics, ACE inhibitors, ARBs, and neprilysin inhibitors, have demonstrated mortality benefits in heart failure.
  • Natural compensatory mechanisms offer temporary symptom relief but ultimately fail in end-stage disease.
  • Mechanical circulatory support serves as a bridge to transplant, while inotropic drugs show limited long-term efficacy and increased mortality.

Conclusions:

  • Accurate diagnosis of HFrEF versus HFpEF is paramount for initiating appropriate heart failure management.
  • While current treatments offer benefits, end-stage heart failure presents significant therapeutic challenges, especially in low and middle-income countries.
  • Continued research is essential to discover novel and more effective treatments for the global heart failure population.