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Closed Bipolar Electrode Array for Optical Reporting Reaction-Coupled Electrochemical Sensing and Imaging.
Xiang Qin1, Jiao Gao1, Hua-Jiang Jin1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 1, 2022
Summary
This review explores closed bipolar electrode (BPE) arrays for electrochemical imaging. These arrays use electro-fluorochromism (EFC) or electro-chemiluminescence (ECL) to detect cellular activities with high spatial resolution.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Biosensing
Background:
- Electrochemical signals are typically detected directly.
- Transducing electrochemical signals into optical signals offers advantages for imaging.
- Closed bipolar electrode (BPE) arrays provide a unique platform for such transduction.
Purpose of the Study:
- To review recent advancements in BPE array-based electro-fluorochromism (EFC) and electro-chemiluminescence (ECL) sensing and imaging.
- To discuss the potential of this technique for high-resolution electrochemical imaging.
- To highlight applications in imaging single-cell activities.
Main Methods:
- Utilizing closed BPE arrays where electrochemical signals at one pole are converted to EFC or ECL signals at the opposite pole.
- Monitoring luminescence signals to detect and image redox reaction currents.
- Summarizing and analyzing recent developments in the field.
Main Results:
- Demonstrated the feasibility of transducing electrochemical signals into EFC/ECL signals using BPE arrays.
- Highlighted the capability of detecting and imaging redox reactions via luminescence.
- Reviewed various recent developments and applications of this technology.
Conclusions:
- Closed BPE arrays offer a promising approach for sensitive electrochemical detection and imaging.
- The technique facilitates the visualization of electrochemical processes through luminescence.
- Future opportunities lie in enhancing spatial resolution for advanced cellular imaging.
