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Updated: Aug 23, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Curcumin Inhibits Invasion and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells by Regulating
1Institute of Neuroscience, Affiliated Taihe Hospital, Hubei University of Medicine, Shiyan, China. jing_zhu0719@163.com.
Abstract:
The molecular mechanisms of flavonoid curcumin used in cancer treatment are not fully understood. The results of this study suggest that curcumin evidently inhibits epithelial-mesenchymal transition, cell growth, and invasion of hepatocellular carcinoma cell lines HepG2 and Huh-7, as well as the Wnt/β-catenin signal pathway. Curcumin might exert anti-tumor effect on hepatocellular carcinoma cells by regulating the TET1/Wnt/β-catenin signal pathway to inhibit the epithelial-mesenchymal transition progress.
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