SPR Based Biosensing Chip for COVID-19 Diagnosis-A Review

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Infectious Disease Diagnostics

Background:

• Surface Plasmon Resonance (SPR) is a label-free optical technique widely used for biomolecular detection.
• Current methods like Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2 diagnosis are time-consuming and costly.
• There is a critical need for rapid, accurate, and sensitive diagnostic tools for the COVID-19 pandemic.

Purpose of the Study:

• To review the development and application of SPR-based biosensing chips for the rapid detection of SARS-CoV-2.
• To highlight the potential of SPR sensors as a portable and efficient diagnostic tool for COVID-19.

Main Methods:

• Review of existing literature on Surface Plasmon Resonance (SPR) biosensor technology.
• Focus on SPR sensor designs and their application in detecting viral pathogens, specifically SARS-CoV-2.
• Analysis of SPR sensor performance characteristics such as speed, accuracy, and sensitivity.

Main Results:

• SPR techniques demonstrate high accuracy in various biomolecular detections, including potential for SARS-CoV-2.
• SPR biosensing chips are emerging as a viable platform for fast and accurate SARS-CoV-2 virus detection.
• SPR sensors offer advantages in speed and portability compared to conventional RT-PCR methods.

Conclusions:

• SPR-based biosensors hold significant promise for rapid, accurate, and portable diagnosis of SARS-CoV-2.
• The development of innovative SPR biosensors is crucial for combating the COVID-19 pandemic.
• SPR technology represents a key advancement in the field of infectious disease diagnostics.