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Updated: Aug 22, 2025
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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
Published on: September 5, 2018
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Influence of claustrum on cortex varies by area, layer, and cell type.
Ethan G McBride1, Saurabh R Gandhi1, Jacqulyn R Kuyat1
1Allen Institute, Seattle, WA 98109, USA.
Neuron
|November 11, 2022
Summary
Claustrum stimulation impacts cortical neurons differently across brain regions, layers, and cell types. This research reveals functional modularity in claustro-cortical circuits, influencing brain activity based on stimulation patterns.
Area of Science:
- Neuroscience
- Computational Neuroscience
Background:
- The claustrum, a subcortical nucleus, has extensive cortical connections.
- Its precise influence on cortical activity, especially outside frontal regions, remains unclear.
Purpose of the Study:
- To investigate the differential effects of claustrum input on cortical activity.
- To elucidate the functional organization of claustro-cortical circuits.
Main Methods:
- Optogenetics and multi-regional Neuropixels recordings in awake mice.
- Recording from over 15,000 cortical neurons to assess responses to claustrum stimulation.
Main Results:
- Claustrum stimulation effects vary by cortical area, layer, and cell type (FS vs. RS neurons).
- Brief stimulation primarily impacts fast-spiking neurons and decreases frontal activity.
- Prolonged stimulation shows region- and layer-specific excitation (posterior, superficial) and inhibition (frontal, deep).
Conclusions:
- Claustro-cortical circuits are organized into distinct functional modules.
- The claustrum exerts complex, spatially organized control over cortical processing.
Keywords:
Neuropixelsanterior cingulate cortexclaustro-cortical interactionsclaustrumoptogeneticsprefrontal cortexretrosplenial cortexsecondary motor cortexMore Related Videos
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