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Orthobiologic Standardization and Clinical Outcome Measurement
Joshua Martin1, Gerard Malanga2
1Washington, DC, USA.
Physical Medicine and Rehabilitation Clinics of North America
|November 21, 2022
Summary
Standardizing orthobiologics is crucial, as variations in cellular components and concentrations impact patient outcomes. Consistent measurement and processing are needed for platelet-rich plasma, bone marrow aspirate, and adipose tissue injections.
Area of Science:
- Orthopedic medicine
- Regenerative medicine
- Biologics development
Background:
- Orthobiologics use cellular therapies to enhance tissue healing.
- Current orthobiologic preparations lack standardized cellular components and concentrations.
- Variability in preparation methods may affect clinical efficacy and patient outcomes.
Purpose of the Study:
- To highlight the urgent need for standardization in orthobiologics.
- To emphasize the importance of measuring cellular constituents and standardizing processing.
- To address the variability in current orthobiologic treatments.
Main Methods:
- Review of existing literature on orthobiologics variability.
- Analysis of factors influencing orthobiologic efficacy (cellular components, concentrations, processing).
- Comparison of measurement techniques for different orthobiologic types.
Main Results:
- Significant evidence suggests cellular factors critically impact patient outcomes.
- Platelet-rich plasma (PRP) and bone marrow aspirate (BMA) allow for cell counting.
- Adipose-derived treatments require standardized processing due to difficult cellular quantification.
Conclusions:
- Standardization of orthobiologics is imperative for consistent and improved patient results.
- Development of standardized measurement protocols for cellular components is necessary.
- Standardized processing techniques for adipose-derived orthobiologics are essential.
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