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Updated: Aug 6, 2025
03:49
Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
19.2K
Perianal Paget's-an aggressive disease
Yaron Rudnicki1, Sahael M Stapleton1, Rishi Batra1
1Division of Colon and Rectal Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Summary
Perianal Paget's disease (PAPD) is an aggressive condition linked to anal adenocarcinoma. This study highlights high rates of synchronous and metachronous malignancy, impacting patient prognosis and treatment strategies.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Dermatology
Background:
- Perianal Paget's disease (PAPD) is a rare malignancy with an uncertain prognosis.
- Previous studies suggested a non-aggressive nature, but updated data is needed.
Purpose of the Study:
- To describe the updated institutional experience with Perianal Paget's disease.
- To analyze clinical manifestations, treatment outcomes, and oncological prognosis.
Main Methods:
- Retrospective review of patients diagnosed with primary PAPD from 1991 to 2021.
- Data collected included demographics, clinical and pathological features, treatments, recurrence, and survival.
Main Results:
- Forty percent of patients had invasive anal adenocarcinoma at diagnosis.
- Twenty-seven percent developed adenocarcinoma concurrently with PAPD recurrence.
- Overall survival was 56% at 15 years, with a median survival of 16 years and 20% disease-related mortality.
Conclusions:
- Perianal Paget's disease is an aggressive entity.
- High rates of synchronous and metachronous anal adenocarcinoma are observed.
- PAPD requires careful monitoring and management due to its association with malignancy.
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