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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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  1. Home
  3. Risk Factors For Small Bowel Crohn's Disease Recurrence After Total Proctocolectomy.
  1. Home
  3. Risk Factors For Small Bowel Crohn's Disease Recurrence After Total Proctocolectomy.

Related Experiment Video

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Risk Factors for Small Bowel Crohn's Disease Recurrence after Total Proctocolectomy.

Maxwell D Mirande1, Ana Sofia Ore1, Emily G Flaherty2

  • 1Division of Colon and Rectal Surgery, Mayo Clinic Rochester, Minnesota, USA.

Diseases of the Colon and Rectum
|June 12, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Patients undergoing surgery for Crohn's disease have a 5-year small bowel recurrence risk of about 20%. A history of small bowel Crohn's disease and younger diagnosis age increase this risk.

Keywords:
ColitisCrohn’s diseaseInflammatory bowel diseaseRecurrenceTotal proctocolectomy with end ileostomy

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Inflammatory Bowel Disease Research

Background:

  • Surgical management of Crohn's disease affecting the colon and rectum often necessitates total proctocolectomy with end ileostomy.
  • Limited data exists regarding the need for Crohn's disease-specific therapy and recurrence rates post-surgery.

Purpose of the Study:

  • To assess the risk of small bowel Crohn's disease recurrence following total proctocolectomy with end ileostomy.
  • To identify risk factors associated with postoperative recurrence.

Main Methods:

  • Retrospective cohort study conducted in a multistate tertiary healthcare system.
  • Included adult patients with Crohn's disease who underwent total proctocolectomy with end ileostomy between 2014-2023.
  • Primary outcome was small bowel Crohn's disease recurrence.

Main Results:

  • 193 patients were analyzed, with a median follow-up of 4.8 years.
  • Small bowel Crohn's disease recurrence occurred in 18.1% of patients, with an estimated 5-year recurrence-free rate of 80.2%.
  • History of small bowel Crohn's disease and diagnosis before age 18 were significant risk factors for recurrence.

Conclusions:

  • Total proctocolectomy with end ileostomy for Crohn's disease carries an approximate 20% risk of small bowel recurrence within 5 years.
  • The risk of requiring surgical intervention for recurrence is low.
  • Patients with prior small bowel Crohn's disease and early-onset diagnosis may benefit from enhanced surveillance and prophylactic medical therapy.