Jove
Visualize
Contact Us

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

571
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
571
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

97
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
97
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

165
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
165
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

213
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
213
What is the Immune System?01:38

What is the Immune System?

112.5K
Overview
112.5K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

379
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
379

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the Connection Between the Gut-Brain Axis and Major Depression: A Theoretical Perspective.

Advances in experimental medicine and biology·2026
Same author

Probiotics and Fecal Microbiota Transplantation in Major Depression: Doxa or Episteme?

Advances in experimental medicine and biology·2024
Same author

A case of myocarditis and isolated hypopotassemia after Biontech-Pfizer vaccine for Covid-19.

Vaccine·2022
Same author

The Changeable Positioning of the Couch and Repositioning to Face-to-Face Arrangement in Psychoanalysis to Facilitate the Experience of Being Seen.

Frontiers in psychology·2021
Same author

Prolonged sertraline use related carcinoembryonic antigen increase.

Indian journal of pharmacology·2021
Same author

Vaccination and Immunotherapy for Major Depression.

Advances in experimental medicine and biology·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 6, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.5K

Microbiome-Induced Autoimmunity and Novel Therapeutic Intervention.

Alper Evrensel1,2

  • 1Department of Psychiatry, Uskudar University, Istanbul, Turkey.

Advances in Experimental Medicine and Biology
|March 23, 2023
PubMed
Summary

The human microbiome is crucial for immune system development and overall health. Disruptions in this interaction are linked to autoimmune diseases, prompting research into new therapeutic strategies.

Keywords:
AutoimmunityDysbiosisLeaky gutMicrobiomeNeuroinflammationVaccination

More Related Videos

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.9K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.6K

Related Experiment Videos

Last Updated: Aug 6, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.5K
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.9K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.6K

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • The human microbiome, a complex microbial community, is integral to host health and immune system development.
  • Host-microbiome interactions are vital for immune tolerance and defense against pathogens.
  • Recent research highlights the role of microbiome dysbiosis in the pathogenesis of autoimmune diseases.

Approach:

  • Reviewing current scientific literature on host-microbiome interactions and autoimmune diseases.
  • Investigating mechanisms such as leaky gut syndrome, dysbiosis, and immune cell dysfunction.
  • Examining emerging therapeutic strategies for modulating the microbiome.

Key Points:

  • Disruptions in the host-microbiome axis are implicated in autoimmune disease development.
  • Key factors include increased intestinal permeability (leaky gut), microbial imbalance (dysbiosis), and altered immune responses.
  • Toll-like receptor signaling and B cell function are critical components of this interaction.

Conclusions:

  • Understanding the intricate relationship between the microbiome and the immune system is essential for autoimmune disease research.
  • Novel therapeutic avenues targeting the microbiome show promise for managing autoimmune conditions.
  • Further research is needed to fully elucidate the mechanisms and optimize treatment strategies.