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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions

Avia Rosenhouse-Dantsker1, Dimitris Gazgalis2, Diomedes E Logothetis2

  • 1Department of Chemistry, University of Illinois Chicago, Chicago, IL, USA. dantsker@uic.edu.

Advances in Experimental Medicine and Biology
|March 29, 2023
PubMed
Summary

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and cholesterol are vital membrane lipids. This chapter explores their structures, functions, and crosstalk, particularly in ion channel regulation.

Keywords:
Cellular signalingCholesterolLipid homeostasisLipid modulation of protein functionLipid regulationPhosphatidylinositol 4,5-bisphosphate

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