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Role of Lysosomal Cholesterol in Regulating PI(4,5)P2-Dependent Ion Channel Function

Eamonn J Dickson1

  • 1Department of Physiology and Membrane Biology, University of California, Davis, CA, USA. ejdickson@ucdavis.edu.

Advances in Experimental Medicine and Biology
|March 29, 2023
PubMed
Summary

Lysosomes regulate neuronal excitability by controlling cholesterol and PI(4,5)P2 levels, which in turn influence ion channel function. This highlights the lysosome's role in cellular signaling and lipid metabolism.

Keywords:
CholesterolIon channelsNiemann Pick Type CPI(4,5)P2Phosphoinositideslysosome

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