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Self-reported Xylazine Experiences: A Mixed Methods Study of Reddit Subscribers
Anthony Spadaro1, Karen O' Connor2, Sahithi Lakamana3
1Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Xylazine is an unwanted adulterant in illicit drugs, causing prolonged sedation and withdrawal symptoms in users, particularly in the Northeastern US. This study highlights xylazine
Area of Science:
- Public Health
- Illicit Drug Use
- Pharmacology
Background:
- Xylazine, an alpha-2 agonist, is increasingly found in the illicit drug supply.
- Understanding its prevalence and effects is crucial for public health.
- People Who Use Drugs (PWUDs) are key informants on its real-world impact.
Conclusions:
- Xylazine is predominantly an unwanted adulterant in the illicit drug supply.
- PWUDs experience significant adverse effects, including prolonged sedation and withdrawal.
- These effects appear more prevalent in the Northeastern United States.
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