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Published on: January 9, 2019
Histopathologic and Molecular Evaluation of Meningioma
1Department of Pathology, University of Utah, Sandy, UT, USA.
Abstract:
Meningiomas are the most common intracranial tumor. This article reviews various aspects of the pathology of these tumors, from their frozen section appearance to the various subtypes a pathologist may come across at the microscope. Special emphasis is placed on the importance of CNS World Health Organization grading by light microscopic means to predict biological behavior of these tumors. Furthermore, relevant literature concerning the potential impact that DNA methylation profiling of these tumors and the possibility that this molecular testing modality might be the next step in refinement of our analysis of meningioma is presented.
Insights
This review covers meningioma pathology, from microscopic appearance to World Health Organization grading. DNA methylation profiling shows promise for refining meningioma analysis and predicting tumor behavior.
Area of Science:
- Neuropathology
- Oncology
- Molecular Pathology
Background:
- Meningiomas represent the most frequent primary intracranial tumors.
- Accurate pathological assessment is crucial for diagnosis and prognosis.
Purpose of the Study:
- To review the pathological spectrum of meningiomas.
- To emphasize the role of World Health Organization grading in predicting tumor behavior.
- To discuss the emerging role of DNA methylation profiling in meningioma classification.
Main Methods:
- Review of literature on meningioma pathology.
- Analysis of frozen section appearance and microscopic subtypes.
- Evaluation of World Health Organization grading criteria.
- Assessment of studies on DNA methylation profiling in meningiomas.
Main Results:
- Meningiomas exhibit diverse microscopic features and subtypes.
- Light microscopic grading is essential for predicting biological behavior.
- DNA methylation profiling offers potential for enhanced diagnostic accuracy and prognostic stratification.
Conclusions:
- Comprehensive pathological evaluation, including grading, is vital for meningioma management.
- DNA methylation profiling represents a promising advancement in meningioma analysis.
- Future research should focus on integrating molecular data into routine diagnostics.
