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Quality Assurance

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...

Quality Control

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Quantitative Analysis

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A Quantitative Fitness Analysis Workflow

A Quantitative Fitness Analysis Workflow

Published on: August 13, 2012

Innovative Quantification of Critical Quality Attributes.

Sotirios Papamatthaiou¹, Despina Moschou²

¹Centre for Biosensors, Bioelectronics and Biodevices (ToC3Bio) and Department of Electronic & Electrical Engineering, University of Bath, Bath, UK.

Advances in Experimental Medicine and Biology

|May 31, 2023

Summary

This summary is machine-generated.

Lab-on-Printed Circuit Board (Lab-on-PCB) technology offers a cost-effective solution for cellular therapy potency testing. This approach enables rapid, portable, and sensitive biomarker quantification, overcoming limitations of traditional methods.

Keywords:

Biosensors Dry film resist Electrochemical sensors Lab-on-Chip Lab-on-PCB MEMS Microfluidic integration PCB technology μTAS

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Concurrent Quantification of Cellular and Extracellular Components of Biofilms

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Published on: December 10, 2013

Area of Science:

Biotechnology and Biomedical Engineering
Analytical Chemistry
Materials Science

Background:

Cellular therapy product evaluation relies heavily on potency testing.
Current in vitro methods face challenges due to product instability, lot variability, and time constraints.
Lab-on-Chip (LOC) technology offers potential for rapid, portable, and sensitive diagnostics.

Purpose of the Study:

To review the progress of Lab-on-Printed Circuit Board (Lab-on-PCB) prototypes for quantifying critical quality attributes in cellular therapy.
To explore the technology, applications, and commercialization potential of Lab-on-PCB for potency testing.

Main Methods:

Review of Lab-on-PCB prototypes for miniaturized microchip-based analyses.
Focus on integration of microfluidics and electronics on a PCB platform.
Assessment of quantification of quality-related biomarkers for potency testing.

Main Results:

Lab-on-PCB demonstrates potential for economical diagnostic platforms by leveraging established PCB manufacturing.
Unique integration capabilities of PCB for microfluidics and electronics in LOC devices.
Prototypes show promise for quantifying critical quality attributes relevant to potency testing.

Conclusions:

Lab-on-PCB technology presents a viable and affordable approach for cellular therapy potency testing.
This technology can overcome current limitations, enabling wider adoption of cellular therapies.
Further development and commercialization of Lab-on-PCB hold significant promise for advancing healthcare diagnostics.