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Paul S Jacobs1, Blake Benyard1, Quy Cao2

  • 1Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Magnetic Resonance in Medicine
|June 6, 2023
PubMed
Summary

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This summary is machine-generated.

Dielectric pads (DP) improve brain imaging at 7 Tesla by correcting magnetic field inhomogeneities. This enhances Nuclear Overhauser effect magnetization transfer ratio (NOEMTR) contrast in the temporal lobes for better brain substructure analysis.

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Biophysics

Background:

  • Nuclear Overhauser effect magnetization transfer ratio (NOEMTR) offers detailed investigation of brain lipids and macromolecules.
  • Increased contrast at 7 Tesla (7T) is beneficial, but B1+ inhomogeneities degrade image quality.
  • High-permittivity dielectric pads (DP) can generate secondary magnetic fields to correct B1+ inhomogeneities.

Purpose of the Study:

  • To demonstrate the efficacy of dielectric pads (DP) in mitigating B1+ inhomogeneities at 7T.
  • To improve NOEMTR contrast, particularly in the temporal lobes, using DP.
  • To assess the impact of DP on B1+ homogeneity and NOEMTR contrast across the brain.

Main Methods:

  • Acquisition of partial 3D NOEMTR contrast images and whole-brain B1+ field maps at 7T in six healthy subjects.
Keywords:
NOEMTRdielectric paddingultra-high field

Related Experiment Videos

  • Placement of calcium titanate dielectric pads (relative permittivity 110) near the temporal lobes.
  • Application of post-processing linear correction to DP-corrected NOEMTR images.

    • Main Results:

    • DP provided supplemental B1+ to temporal lobes and reduced it in posterior/superior regions, enhancing B1+ homogeneity.
    • A statistically significant increase in NOEMTR contrast was observed in temporal lobe substructures.
    • DP usage led to a convergence of NOEMTR contrast values, indicating more uniform contrast across the brain slab.

    Conclusions:

    • Dielectric pads significantly improve NOEMTR contrast in the temporal lobes at 7T by increasing B1+ homogeneity.
    • DP-derived improvements enhance the robustness of brain substructural measures.
    • This technique holds promise for both healthy and pathological brain imaging applications.