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An Overview.

Xin Li1,2, Caishui Yang1,2,3, Jun Wang4,5

  • 1State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China.

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Summary
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China

Keywords:
Active agingAging brainAlzheimer’s disease (AD)Beijing Aging Brain Rejuvenation Initiative (BABRI)Brain healthDementia

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • China faces significant public health challenges due to its rapidly aging population.
  • Brain structure and function change with age, increasing cognitive decline and dementia risk in the elderly.
  • The systemic mechanisms of the aging brain remain incompletely understood.

Purpose of the Study:

  • To define brain health in the context of aging.
  • To outline the aging demographic landscape in China.
  • To introduce the Brain Aging and Biomarkers Research Initiative (BABRI) and its contributions to understanding brain aging.

Main Methods:

  • This chapter provides a foundational overview, setting the stage for detailed discussions in subsequent chapters.
  • It defines key concepts related to brain health and aging.
  • It reviews the current aging situation in China and introduces the BABRI framework.

Main Results:

  • The chapter establishes the critical need for a comprehensive understanding of brain aging.
  • It highlights the unique challenges posed by China's aging society.
  • It introduces a framework (BABRI) to investigate healthy and pathological brain aging.

Conclusions:

  • A systemic understanding of brain aging is crucial for addressing public health challenges in aging societies like China.
  • This work aims to elucidate the mechanisms underlying both healthy and pathological brain aging.
  • The presented framework and chapter introductions lay the groundwork for future research into cognitive decline and dementia prevention.