Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating community Live Reviews into academic publishing: an exploratory study.

Research integrity and peer review·2026

Same author

Dementia and hearing loss: from risk to mechanisms and management.

Frontiers in dementia·2026

Same author

Neuronal effects of epicranial current stimulation in macaque cortex.

Frontiers in neuroscience·2025

Same author

Phase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells.

Hippocampus·2025

Same author

Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia.

Cell reports·2024

Same author

Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations.

Scientific reports·2023

Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026

Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026

Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026

Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026

Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026

Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 20, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Structural Connectivity Changes After Fornix Transection in Macaques Using Probabilistic Diffusion Tractography.

Vassilis Pelekanos¹, Elsie Premereur², Anna S Mitchell^3,4

¹School of Medicine, University of Nottingham, Nottingham, UK. v.pelekanos@nottingham.ac.uk.

Advances in Experimental Medicine and Biology

|July 31, 2023

Summary

This summary is machine-generated.

Fornix transection in macaques altered brain connectivity, particularly between the anterior thalamus, CA3, and ACC. These changes reveal potential indirect pathways supporting memory after brain damage.

Keywords:

Anterior cingulate Anterior thalamus Diffusion-weighted MRI Fornix Hippocampus Probabilistic tractography Retrosplenial cortex

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Related Experiment Videos

Last Updated: Jul 20, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Area of Science:

Neuroscience
Neuroimaging
Systems Neuroscience

Background:

The fornix is a critical white matter tract in the limbic system, essential for learning and memory.
Understanding fornix damage effects on brain networks is vital for memory research.

Purpose of the Study:

To investigate structural connectivity changes in cortical and subcortical regions following fornix transection in nonhuman primates (NHPs).
To identify potential indirect neural pathways that may compensate for memory functions after fornix damage.

Main Methods:

Diffusion-weighted MRI (dMRI) data were collected from macaque monkeys before and after bilateral fornix transection or sham surgery.
Probabilistic tractography was used to quantify structural connectivity between predefined regions of interest (ROIs).

Main Results:

Forix-transected NHPs showed significant connectivity alterations compared to controls.
Increased connectivity was observed between the anterior thalamus and anterior cingulate cortex (ACC), and between the CA3 and ACC.
Decreased connectivity was found between the CA3 hippocampal subfield and the retrosplenial cortex (RSC).

Conclusions:

Fornix transection induces substantial changes in cortical and subcortical network connectivity.
The study identifies candidate indirect routes, such as those involving the ACC, that may play a role in maintaining memory functions post-injury.