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Updated: Jul 19, 2025

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Assaying the Kinase Activity of LRRK2 in vitro
Published on: January 18, 2012
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Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently
Wei Wang1,2, Xuan Wang1, Guanghui Tang2
1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518000, China. gaolq@mail.sysu.edu.cn.
Abstract:
Herein, we report a salicylaldehyde-based, reversible covalent inhibitor (A2) that possesses moderate cellular activity against AURKA with a prolonged residence time and shows significant non-covalent inhibition towards LRRK2. Our results indicated that this multitarget kinase inhibitor may be used as the starting point for future development of more potent, selective and dual-targeting covalent kinase inhibitors against AURKA and LRRK2 for mitophagy.

