Related Experiment Video
Updated: Jul 17, 2025
09:35
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
9.8K
Optimizing Skin Regenerative Response to Calcium Hydroxylapatite Microspheres Via Poly-Micronutrient Priming
Journal of Drugs in Dermatology : JDD
|September 8, 2023
Summary
Priming aging skin with NCTF 135 HA before calcium hydroxylapatite (CaHA) treatments enhances regenerative effects. This combination therapy improved skin aesthetics, laxity, wrinkles, and thickness in all patients.
Area of Science:
- Regenerative medicine
- Aesthetic dermatology
- Skin biology
Background:
- Regenerative aesthetics focuses on restoring aging skin structure and function.
- Calcium hydroxylapatite (CaHA) and NCTF 135 HA are established minimally invasive treatments.
- Suboptimal patient response to regenerative treatments suggests potential contributing factors like micronutrient deficiencies.
Purpose of the Study:
- To investigate if "priming" skin with NCTF 135 HA enhances the clinical effects of CaHA.
- To explore the hypothesis that micronutrient deficiencies impact treatment responsiveness.
- To introduce a novel approach of using an amino acid-based diluent for regenerative biostimulators.
Main Methods:
- A case series design was employed.
- Patients received a combination treatment involving "priming" with NCTF 135 HA followed by CaHA.
- The study focused on evaluating the synergistic effects of this combined approach.
Main Results:
- The combination treatment led to 100% patient improvement after a single session.
- Observed improvements included panfacial aesthetics, skin laxity, wrinkle severity, luminosity, and hyperpigmentation.
- Significant increases in skin and subcutis thicknesses were noted.
Conclusions:
- Priming the skin with NCTF 135 HA can significantly enhance the regenerative response to CaHA treatments.
- This novel "skin priming" technique, using an amino acid-based diluent, offers a promising strategy for optimizing skin rejuvenation.
- The findings suggest a nutritional component, potentially addressed by NCTF 135 HA, is crucial for maximizing protein synthesis and extracellular matrix regeneration.
