Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new
Andrew J Hall1, Amy G Robertson1, Robert W Baker1
1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
Chemical Communications (Cambridge, England)
|October 4, 2023
Abstract:
The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching 1200%, over the parent triphenylphosphonium salts. DFT and quantum chemical topology analyses support a new type of conformationally-dependent tumour cell targeting vector.
