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Reversible membranous glomerulonephritis associated with ketoprofen.
Clinical Nephrology
|October 1, 1986
Summary
A woman developed nephrotic syndrome after taking ketoprofen for osteoarthritis. Kidney biopsy revealed membranous glomerulonephritis, which resolved after discontinuing the drug and receiving steroids.
Area of Science:
- Nephrology
- Pharmacology
- Immunopathology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation.
- Drug-induced nephropathy is a recognized adverse effect of NSAID use.
- Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Observation:
- An 87-year-old female patient presented with nephrotic syndrome.
- The patient had a history of osteoarthritis treated with ketoprofen (100 mg daily) for 12 months.
- Clinical and laboratory findings were indicative of drug-induced nephropathy.
Findings:
- Kidney biopsy confirmed membranous glomerulonephritis.
- Proteinuria resolved following the withdrawal of ketoprofen.
- Treatment with steroids further contributed to the favorable outcome.
Implications:
- This case highlights an unusual presentation of NSAID-induced nephropathy.
- Membranous glomerulonephritis is a rare complication of NSAID use.
- Early recognition and drug withdrawal are crucial for managing drug-induced kidney injury.