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Light-Driven Radiochemistry with Fluorine-18, Carbon-11 and Zirconium-89
Daniel Lin1,2, Laura M Lechermann1, Malcolm P Huestis3
1Department of Translational Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Angewandte Chemie (International Ed. in English)
|December 22, 2023
Summary
Recent advances in light-driven radiochemistry accelerate the development of novel positron emission tomography (PET) radiotracers. Photochemistry is enhancing the synthesis of fluorine-18, carbon-11, and zirconium-89 labeled compounds for medical imaging.
Area of Science:
- Radiochemistry
- Photochemistry
- Medical Imaging
Background:
- Positron Emission Tomography (PET) relies on radiotracers for disease diagnosis.
- Traditional radiochemistry methods face limitations in efficiency and scope.
- Light-driven (photo-mediated) radiochemistry offers new synthetic pathways.
Purpose of the Study:
- To review recent advancements in light-driven radiochemistry for key PET isotopes.
- To highlight applications of these methods in synthesizing novel PET radiotracers.
- To discuss the integration of photochemistry into radiopharmaceutical development.
Main Methods:
- Focus on light-mediated radiochemistry for fluorine-18, carbon-11, and zirconium-89.
- Discuss activation of substrates or radiolabeled reagents using light.
- Describe postlabeling click reactions for large biomolecules with zirconium-89.
Main Results:
- Fluorine-18 radiochemistry utilizes light to activate [18F]fluoride or derived reagents.
- Carbon-11 photo-mediated methods enable diverse small molecule radiolabeling (methylation, carboxylation, etc.).
- Zirconium-89 photo-mediated radiochemistry facilitates efficient labeling of monoclonal antibodies (mAbs).
Conclusions:
- Technological integration, like photoreactors in radiosynthesizers, signifies growing adoption of photochemistry.
- Photo-mediated radiochemistry expands retrosynthetic strategies for novel PET tracer discovery.
- These advances are crucial for developing next-generation PET imaging agents.
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