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The Effects of Threefold 30-Minute Inhalation Sessions of an Argon-Oxygen Mixture on a Photochemically Induced Ischemic Stroke Model in Rats.

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Positive Neuroprotective Effect of Argon Inhalation after Photochemically Induced Ischemic Stroke Model in Rats.

D N Silachev1, E A Boeva2, E I Yakupova3

  • 1A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia. d_silachev@oparina4.ru.

Bulletin of Experimental Biology and Medicine
|January 8, 2024
PubMed
Summary

Inhaling an argon-oxygen mixture for 2 hours daily over three days significantly reduced brain damage and neurological deficits in rats following a stroke. This study highlights a potential therapeutic approach for stroke recovery.

Keywords:
argonischemianeuroprotective propertiesphotochemically induced stroke

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pharmacology

Background:

  • Ischemic stroke remains a leading cause of long-term disability.
  • Current treatments for stroke are limited, necessitating novel therapeutic strategies.
  • Noble gas inhalation therapy is an emerging area of research for neuroprotection.

Purpose of the Study:

  • To investigate the neuroprotective effects of argon-oxygen (Ar-O2) mixture inhalation in a rat model of photochemical stroke.
  • To evaluate the impact of Ar-O2 inhalation on neurological deficit severity and brain damage volume.

Main Methods:

  • Photochemical stroke was induced in Wistar rats.
  • Rats inhaled an Ar-O2 mixture (70%/30%) for 2 hours daily on days 1, 2, and 3 post-stroke.
  • Neurological deficit was assessed using the limb placement test over 14 days.
  • Brain damage was quantified using Magnetic Resonance Imaging (MRI) and histological analysis on day 14.

Main Results:

  • Rats treated with Ar-O2 showed significantly improved limb placement scores on days 3, 7, and 14 compared to controls (ischemia + N2-O2).
  • MRI analysis revealed that Ar-O2 inhalation halved the volume of the ischemic brain lesion.
  • Histological examination corroborated the MRI findings, indicating reduced brain tissue damage.

Conclusions:

  • Daily 2-hour inhalation of an argon-oxygen mixture effectively mitigates neurological deficits and reduces brain damage volume in a rat stroke model.
  • Ar-O2 inhalation presents a promising, non-invasive therapeutic strategy for post-stroke recovery.
  • Further research is warranted to explore the underlying mechanisms and clinical applicability of this treatment.