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Handheld Biosensor System Based on a Gradient Grating Period Guided-Mode Resonance Device.

Chien Chieh Chiang1, Wen-Chun Tseng1, Wen-Tsung Tsai1

  • 1Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

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|January 22, 2024
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Summary
This summary is machine-generated.

This study introduces a novel handheld biosensor using a gradient grating period guided-mode resonance (GGP-GMR) sensor for accurate analyte detection. The GGP-GMR biosensor achieved low limits of detection for bulk solutions and multiplexed analytes.

Keywords:
albumincreatinineguided-mode resonancehandheld biosensor deviceoptical biosensor

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Area of Science:

  • * Photonics and Sensor Technology
  • * Biomedical Engineering
  • * Analytical Chemistry

Background:

  • * Handheld biosensors are crucial for disease diagnosis, drug monitoring, and environmental sensing.
  • * Conventional guided-mode resonance (GMR) sensors have limitations in precise analyte quantification.
  • * Gradient grating period (GGP) designs offer potential for enhanced biosensing capabilities.

Purpose of the Study:

  • * To develop and validate a novel handheld biosensor utilizing a GGP-GMR sensor.
  • * To investigate the optimization of optical components and substrate materials for improved sensor performance.
  • * To assess the limit of detection (LOD) for bulk solutions and multiplexed analytes.

Main Methods:

  • * Fabrication of an optofluidic chip with an embedded GGP-GMR sensor.
  • * Integration of a light-emitting diode (LED) light source, optics, and a complementary metal oxide semiconductor (CMOS) detector.
  • * Optimization of LED beam angles, bandpass filters, substrate refractive indices, and waveguide thicknesses.

Main Results:

  • * The GGP-GMR biosensor achieved a limit of detection (LOD) of 1.09 × 10-3 RIU for bulk solutions.
  • * Multiplexed detection of albumin and creatinine demonstrated LODs of 0.66 μg/mL and 0.61 μg/mL, respectively.
  • * Optimized optical parameters and substrate materials enhanced dark band quality and image analysis accuracy.

Conclusions:

  • * The developed handheld GGP-GMR biosensor offers a sensitive and accurate platform for analyte detection.
  • * The linear relationship between resonant wavelength and grating period enables precise concentration monitoring.
  • * This technology holds promise for point-of-care diagnostics and real-time environmental monitoring.