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Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors01:15

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The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
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Related Experiment Video

Updated: Nov 7, 2025

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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A Compact Detection Platform Based on Gradient Guided-Mode Resonance for Colorimetric and Fluorescence Liquid Assay

Jing-Jhong Gao1, Ching-Wei Chiu1, Kuo-Hsing Wen2

  • 1Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

Sensors (Basel, Switzerland)
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

A compact spectral detection system using a gradient grating period guided-mode resonance (GGP-GMR) filter enables sensitive quantification of fluorescent and colorimetric assays. This technology shows promise for point-of-care applications with its small size and high performance.

Keywords:
albumincolorimetric assayscreatininefluorescence detectionguided-mode resonancespectral detectionsubwavelength grating

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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
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Area of Science:

  • Optical Engineering
  • Biomedical Sensing
  • Analytical Chemistry

Background:

  • Traditional spectral detection systems can be bulky and expensive.
  • There is a need for compact, sensitive detection systems for point-of-care diagnostics.

Purpose of the Study:

  • To develop and demonstrate a compact spectral detection system for fluorescent and colorimetric assays.
  • To evaluate the system's performance against a commercial spectrometer.

Main Methods:

  • Integration of a gradient grating period guided-mode resonance (GGP-GMR) filter with a charge-coupled device.
  • Direct measurement of fluorescence emission and spectral analysis.
  • Quantification of albumin (fluorescent and colorimetric) and creatinine (colorimetric) assays.

Main Results:

  • The GGP-GMR filter achieved a spectral detection range of 500-700 nm in a <2.5 mm device.
  • The system accurately detected peak wavelength and intensity for fluorescent assays.
  • Achieved limits of detection (LODs) of 40.99 mg/L (fluorescent albumin), 398 mg/L (colorimetric albumin), and 25.49 mg/L (colorimetric creatinine).

Conclusions:

  • The proposed compact spectral detection system demonstrates high sensitivity and accuracy for common liquid assays.
  • The system's performance is comparable to commercial spectrometers.
  • The GGP-GMR filter's design offers potential for integration into lab-on-a-chip systems for point-of-care applications.