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Related Concept Videos

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Related Experiment Video

Updated: Jul 3, 2025

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
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Evaluation of Intracardiac Pressures Using Subharmonic-aided Pressure Estimation with Sonazoid Microbubbles.

Cara Esposito1, Priscilla Machado1, Maureen E McDonald1

  • 1From the Departments of Radiology (C.E., P.M., F.F., J.K.D.), Medical Imaging and Radiation Sciences (M.E.M.), and Medicine (M.P.S., D.F., P.M., I.S.C., N.R., P.W., A.V., M.D.), Thomas Jefferson University, Philadelphia, Pa; Clarius Mobile Health, Vancouver, Canada (K.D.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.K.D).

Radiology. Cardiothoracic Imaging
|February 15, 2024
PubMed
Summary

The subharmonic-aided pressure estimation (SHAPE) technique shows promise for noninvasively measuring right ventricular systolic and left ventricular diastolic pressures using Sonazoid microbubbles, potentially reducing the need for invasive cardiac catheterization.

Keywords:
AortaCardiacLeft VentricleRight VentricleUltrasound-Contrast

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Area of Science:

  • Cardiovascular Imaging and Diagnostics
  • Ultrasound Contrast Agents
  • Hemodynamic Monitoring

Background:

  • Accurate measurement of right ventricular (RV) systolic and left ventricular (LV) diastolic pressures is crucial for diagnosing and managing cardiovascular diseases.
  • Current methods often rely on invasive cardiac catheterization, which carries inherent risks and limitations.
  • Noninvasive techniques are sought to provide safer and more accessible hemodynamic assessments.

Purpose of the Study:

  • To evaluate the feasibility of the subharmonic-aided pressure estimation (SHAPE) technique for noninvasively determining RV systolic and LV diastolic pressures.
  • To assess the accuracy of SHAPE using Sonazoid microbubbles compared to standard cardiac catheterization methods.

Main Methods:

  • A prospective clinical trial enrolled patients undergoing left and/or right heart catheterization.
  • Sonazoid microbubbles were administered intravenously, and SHAPE data were acquired synchronously with invasive pressure measurements (fluid-filled and solid-state catheters).
  • A conversion factor derived from cuff-based pressure and aortic subharmonic signals was used to translate SHAPE signals into pressure values.

Main Results:

  • The SHAPE technique demonstrated mean errors of 1.6 mm Hg ± 1.5 for RV systolic pressure and 8.4 mm Hg ± 6.2 for LV minimum diastolic pressure compared to fluid-filled catheters.
  • Errors for LV end-diastolic pressure were 7.4 mm Hg ± 5.7 (vs. fluid-filled) and 6.8 mm Hg ± 3.3 (vs. solid-state).
  • The SHAPE technique showed potential for clinically relevant pressure measurements, with P-values indicating statistical significance or near-significance for most comparisons.

Conclusions:

  • The SHAPE technique, when used with Sonazoid microbubbles, shows potential for noninvasive estimation of RV systolic and LV diastolic pressures.
  • This noninvasive approach may offer a valuable alternative to invasive cardiac catheterization for hemodynamic assessment.
  • Further validation and clinical implementation are warranted to establish its role in cardiovascular diagnostics.