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Light Responsive DNA Nanomaterials and Their Biomedical Applications
Raja Muhammad Aqib1,2, Arsalan Umer1,2, Jialin Li1
1CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190, China.
Chemistry, an Asian Journal
|March 21, 2024
Summary
This review highlights light-responsive DNA nanomaterials for biomedical uses. These advanced materials enable precise bioimaging and targeted drug delivery, paving the way for future innovations in medicine.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Molecular Biology
Background:
- DNA nanomaterials are versatile tools in biomedical applications.
- Chemical modifications allow for the integration of stimuli-responsive elements into DNA nanomaterials.
- Light-responsive DNA nanomaterials offer precise control over biological processes.
Purpose of the Study:
- To review recent advancements in light-responsive DNA nanomaterials.
- To explore their applications in bioimaging and drug delivery.
- To discuss current challenges and future directions.
Main Methods:
- Summarizing research on photocleavage/photodecage, photoisomerization, and photocrosslinking in DNA nanomaterials.
- Analyzing applications in imaging small molecules, microRNAs, and proteins.
- Evaluating drug delivery systems for small molecules, nucleic acids, and gene editing tools.
Main Results:
- Light-responsive DNA nanomaterials demonstrate significant potential for enhanced bioimaging.
- These nanomaterials facilitate efficient and targeted drug delivery systems.
- Various light-responsive mechanisms offer tunable control for biomedical applications.
Conclusions:
- Light-responsive DNA nanomaterials are a promising platform for advanced biomedical applications.
- Further research is needed to overcome existing challenges and fully realize their potential.
- Future perspectives include refined control and expanded therapeutic applications.
