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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Updated: Jun 26, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic Dermatitis Disease Complications.

Alyssa G Ashbaugh1, Shawn G Kwatra1

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology
|May 9, 2024
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis increases infection risk due to immune issues and poor skin barrier. Environmental triggers and treatments can worsen flares and lead to serious conditions like lymphoma.

Keywords:
AllergensAtopic dermatitisCutaneous infectionsEczema herpeticumFilaggrin mutationHerpes simplex virusImmune dysregulationMicrobiome changesStaphylococcus aureusSuperantigen

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Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • AD is characterized by immune dysregulation and impaired skin barrier function.
  • This vulnerability increases susceptibility to infections and environmental triggers.

Purpose of the Study:

  • To describe infectious complications associated with atopic dermatitis.
  • To explore the relationship between atopic dermatitis and infectious diseases.
  • To discuss environmental triggers, treatment complications, and associated serious conditions.

Main Methods:

  • Literature review of infectious complications in atopic dermatitis.
  • Analysis of immunological and skin barrier defects in AD.
  • Examination of environmental factors and treatment outcomes.

Main Results:

  • Bacterial, viral, and fungal infections are common complications of atopic dermatitis.
  • Impaired skin barrier and immune dysregulation are key factors.
  • Environmental agents can precipitate disease flares, and treatments may cause complications.

Conclusions:

  • Atopic dermatitis patients face increased risks of various infections.
  • Understanding the interplay between AD, infections, and environment is crucial.
  • Potential links to serious conditions like lymphoma warrant further investigation.