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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
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Vein of Galen Malformations
Alex Devarajan1, Daryl Goldman1, Tomoyoshi Shigematsu1
1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neurosurgery Clinics of North America
|May 23, 2024
Summary
Vein of Galen malformations (VOGMs) treatment focuses on endovascular embolization, with medical and surgical options for symptom control. Future VOGM therapies may benefit from new genomic research and improved endovascular techniques.
Area of Science:
- Neurology
- Pediatric Neurology
- Vascular Neurology
Background:
- Vein of Galen malformations (VOGMs) are rare, complex cerebrovascular anomalies in infants.
- Diagnosis and management of VOGMs have evolved significantly over recent decades.
- Current treatment strategies aim to reduce hemodynamic stress and prevent complications.
Purpose of the Study:
- To review current diagnostic and management strategies for VOGMs.
- To highlight the role of endovascular techniques in VOGM treatment.
- To discuss future directions in VOGM therapy, including technological and genomic advancements.
Main Methods:
- Review of current literature on VOGM diagnosis and management.
- Emphasis on endovascular approaches, including transarterial and transvenous embolization.
- Discussion of adjunctive medical and neurosurgical interventions.
Main Results:
- Staged transarterial embolization remains the primary treatment modality for VOGMs.
- Transvenous embolization, medical therapy, and neurosurgery are used adjunctively.
- Innovations in endovascular technology are improving treatment outcomes.
Conclusions:
- Multidisciplinary management is crucial for optimizing VOGM patient outcomes.
- Advancements in endovascular techniques offer improved therapeutic options.
- Emerging genomic research presents potential for novel VOGM treatment targets.
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