Micronano Synergetic Three-Dimensional Bioelectronics: A Revolutionary Breakthrough Platform for Cardiac Electrophysiology
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Published on: March 21, 2025
Jilin Zheng1, Jiaru Fang2, Dongxin Xu2
1Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310058, China.
Insights
Three-dimensional (3D) micronano bioelectronic devices offer high-quality intracellular recordings for studying cardiac electrophysiology. These advanced devices are crucial for developing new treatments for cardiovascular diseases and improving drug screening.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Nanotechnology
Background:
- Cardiovascular diseases (CVDs) are a leading cause of mortality globally.
- Cardiac electrophysiology is vital for understanding and treating conditions like arrhythmia.
- Accurate, long-term monitoring of cardiomyocyte electrophysiological activity is essential for advancing cardiology and pharmacology.
Purpose of the Study:
- To review the manufacturing, design, and application of 3D micronano bioelectronic devices for cardiac electrophysiology.
- To highlight the advantages of 3D devices over planar designs for intracellular signal recording.
- To discuss current challenges and future directions in the field.
Main Methods:
- Review of existing literature on micronano bioelectronic devices for electrophysiological studies.
- Analysis of electrode geometry and penetration strategies in 3D devices.
- Examination of applications in drug screening and disease modeling.
Main Results:
- Planar devices show limitations in signal strength and quality for extracellular recordings.
- 3D multielectrode/multitransistor arrays achieve high-quality intracellular signal recording through advanced penetration.
- 3D devices enable precise drug screening and biomimetic disease modeling.
Conclusions:
- 3D micronano bioelectronic devices represent a significant advancement for intracellular electrophysiological recording.
- Further development of these platforms is needed to meet emerging clinical demands.
- These technologies promise to enhance the study and treatment of cardiovascular diseases.
Abstract:
Cardiovascular diseases (CVDs) are the leading cause of mortality and therefore pose a significant threat to human health. Cardiac electrophysiology plays a crucial role in the investigation and treatment of CVDs, including arrhythmia. The long-term and accurate detection of electrophysiological activity in cardiomyocytes is essential for advancing cardiology and pharmacology. Regarding the electrophysiological study of cardiac cells, many micronano bioelectric devices and systems have been developed. Such bioelectronic devices possess unique geometric structures of electrodes that enhance quality of electrophysiological signal recording. Though planar multielectrode/multitransistors are widely used for simultaneous multichannel measurement of cell electrophysiological signals, their use for extracellular electrophysiological recording exhibits low signal strength and quality. However, the integration of three-dimensional (3D) multielectrode/multitransistor arrays that use advanced penetration strategies can achieve high-quality intracellular signal recording. This review provides an overview of the manufacturing, geometric structure, and penetration paradigms of 3D micronano devices, as well as their applications for precise drug screening and biomimetic disease modeling. Furthermore, this review also summarizes the current challenges and outlines future directions for the preparation and application of micronano bioelectronic devices, with an aim to promote the development of intracellular electrophysiological platforms and thereby meet the demands of emerging clinical applications.
