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Updated: May 3, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach
Antonella Ilenia Alfano1, Megan Smyth2, Scott Wharry2
1School of Chemistry, University College Dublin, Science Centre South, Dublin 4, Ireland. marcus.baumann@ucd.ie.
Abstract:
A new photochemical CSTR system capable of handling solids in scaled continuous processes is presented. High-power UV-LEDs are integrated in these CSTRs containing an insoluble base that aids in generating pyrazolines via cycloaddition between alkenes and in situ generated diazo species. Contrary to reported batch methods product degradation via ring contraction is suppressed whilst generating gram quantities of spirocyclic pyrazolines.
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