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Advanced Brain Imaging in Central Nervous System Demyelinating Diseases
Alessandro Cagol1, Charidimos Tsagkas2, Cristina Granziera3
1Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Hegenheimermattweg 167b, 4123 Allschwil, Switzerland; Department of Neurology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Spitalstrasse 2, 4031 Basel, Switzerland; Department of Health Sciences, University of Genova, Via A. Pastore, 1 16132 Genova, Italy. Electronic address: https://twitter.com/CagolAlessandr0.
Neuroimaging advances enhance understanding of central nervous system demyelinating diseases like multiple sclerosis. These techniques aid in diagnosis, prognosis, and personalized treatment strategies for better patient outcomes.
Area of Science:
- Neuroscience
- Radiology
- Immunology
Background:
- Central nervous system demyelinating diseases significantly impact neurological function.
- Accurate diagnosis and management are crucial for patient prognosis.
- Traditional diagnostic methods have limitations in characterizing disease complexity.
Purpose of the Study:
- To review state-of-the-art neuroimaging modalities for demyelinating diseases.
- To explore the application of advanced techniques in multiple sclerosis, neuromyelitis optica spectrum disorders, and MOGAD.
- To highlight the potential of neuroimaging in personalized clinical management.
Main Methods:
- Review of current literature on advanced neuroimaging techniques.
- Focus on acquisition and postprocessing methods.
- Application of modalities to specific demyelinating diseases.
Main Results:
- Advanced neuroimaging characterizes focal, diffuse, and macroscopic pathological changes.
- Techniques provide detailed insights into disease mechanisms.
- Integration of multimodal imaging data enhances diagnostic accuracy.
Conclusions:
- Neuroimaging is pivotal in understanding and managing CNS demyelinating diseases.
- Cutting-edge modalities offer promise for differential diagnosis and prognosis.
- Personalized treatment strategies and patient stratification are facilitated by advanced imaging.
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