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Swyer-James Syndrome: A Rare Radiological Report of Two Cases Presenting in Adulthood
Khavin Kumar1, Jeffrey S Joseph1, Ramprasath Sathiamoorthy1
1Department of Radiology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, IND.
Cureus
|July 26, 2024
Summary
Swyer-James syndrome (SJS) presents as unilateral lung hyperlucency, often missed in childhood. Radiological findings are key for diagnosing SJS, especially when patient history is unclear.
Area of Science:
- Pulmonology
- Radiology
- Pediatric Medicine
Background:
- Swyer-James syndrome (SJS), or MacLeod syndrome, is an acquired lung condition resulting from childhood infections.
- It can be asymptomatic in childhood, leading to delayed diagnosis in adulthood as an incidental finding.
Observation:
- Two cases of SJS are presented, one with typical unilateral hyperlucency and childhood infection history.
- A unique case demonstrated unilateral hyperlucency with bilateral mosaic pattern on CT, despite no history of childhood infections.
Findings:
- Radiological findings, including unilateral lung hyperlucency and mosaic patterns, are crucial for diagnosing SJS.
- Diagnostic challenges arise when clinical presentation and patient history are inconclusive.
Implications:
- Accurate radiological diagnosis of SJS is vital for appropriate patient management.
- This highlights the importance of recognizing specific imaging patterns in diagnosing rare pulmonary conditions.

