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Updated: Jun 16, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Rh(III)-Catalyzed C(sp3)-H Thiolation of 8-Methylquinolines Promoted by Benzoic Anhydride
Cheng-Kai Yuan1, Yan-Nian Pan1, Yi-Fei Wu2
1Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
Abstract:
Herein, we developed a ligand-promoted Rh(III)-catalyzed C(sp3)-H thiolation of 8-methylquinolines. The effect of ligands on improving the activity of the catalytic centers has been studied in detail and proven to be significant. Various substituents are well tolerated under this reaction condition to provide potential precursors for organic synthesis. The mechanistic study suggests that the reaction may proceed through a five-membered rhodacycle intermediate via thiolation twice.
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