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A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for
Aesthetic Surgery Journal
|August 23, 2024
Summary
Poly-D,L-lactic acid (PDLLA) demonstrates comparable efficacy to hyaluronic acid for correcting nasolabial folds. This injectable filler is safe and well-tolerated, offering a viable option for soft tissue volume restoration.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Biomaterials Science
Background:
- Injectable poly-D,L-lactic acid (PDLLA) is a biocompatible, biodegradable filler for soft tissue volume loss.
- Its efficacy and safety require further investigation in larger patient cohorts.
Purpose of the Study:
- To evaluate the efficacy and safety of a novel PDLLA dermal filler.
- To compare PDLLA with hyaluronic acid for nasolabial fold correction.
Main Methods:
- A multicenter, evaluator-blinded, randomized controlled trial.
- 260 patients with moderate to severe nasolabial folds received PDLLA or hyaluronic acid.
- Evaluations included Wrinkle Severity Rating Scale (WSRS) and Global Aesthetic Improvement Scale (GAIS) over 52 weeks.
Main Results:
- At 24 weeks, 67.6% of PDLLA patients showed ≥1 grade WSRS improvement vs. 60.9% in the hyaluronic acid group (P < .05).
- PDLLA consistently demonstrated greater WSRS improvement than the control group at all visits.
- PDLLA was found to be safe and well-tolerated, with no severe adverse events reported.
Conclusions:
- PDLLA is non-inferior to hyaluronic acid for correcting nasolabial folds.
- PDLLA represents a safe and effective option for aesthetic facial rejuvenation.
