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Updated: Jun 6, 2025
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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
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Epigenetic Modulations by Microbiome in Breast Cancer
Yuanji Zhao1, Sanchita Bhatnagar2
1Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, USA.
Advances in Experimental Medicine and Biology
|November 25, 2024
Summary
The microbiome influences breast cancer by altering epigenetic mechanisms. Understanding this gut-epigenetic crosstalk may reveal new therapeutic strategies for breast cancer patients.
Area of Science:
- Microbiology
- Epigenetics
- Oncology
Background:
- The microbiome plays a crucial role in host physiology.
- Altered microbiome composition is linked to cancer development and progression.
- Epigenetic dysregulation contributes to breast cancer onset and advancement.
Purpose of the Study:
- To review epigenetic mechanisms in mammalian gene expression.
- To summarize host-associated microbiota and their influence on cancer.
- To explore the interplay between the microbiome and epigenetics in breast cancer.
Main Methods:
- Literature review of epigenetic mechanisms.
- Analysis of host-associated microbiota distribution.
- Synthesis of current research on microbiome-epigenetic interactions in cancer.
Main Results:
- The microbiome can modulate epigenetic mechanisms globally and at specific genes.
- Cross-talk between the microbiome and epigenetics impacts breast cancer progression.
- Epigenetic aberrations in key genes are implicated in breast cancer.
Conclusions:
- The relationship between epigenetics and the microbiome is complex and influences breast cancer.
- Further understanding of this interplay is crucial for developing novel therapeutic strategies.
- Targeting the microbiome-epigenetic axis may offer new avenues for breast cancer treatment.
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