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Advances in Epigenetic Therapeutics for Breast Cancer

Michel-Gael F Guefack1, Sanchita Bhatnagar2

  • 1Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, USA.

Advances in Experimental Medicine and Biology
|November 25, 2024
PubMed

Insights

Epigenetic alterations drive breast cancer progression and treatment resistance. Targeting these epigenetic changes, through enzyme inhibitors or combined therapies, offers promising new strategies for breast cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic deregulation is a key driver in breast cancer, influencing tumor development, therapeutic resistance, and metastasis.
  • Aberrant epigenomic mechanisms are prevalent in breast cancer, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review the targeting of epigenetic mechanisms in breast cancer therapy.
  • To highlight current epigenetic research for developing novel breast cancer treatments.

Main Methods:

  • Review of current literature on epigenetic mechanisms in breast cancer.
  • Analysis of selective inhibitors of epigenetic enzymes.
  • Evaluation of combined epigenetic therapies with conventional treatments.

Main Results:

  • Epigenetic alterations are strongly linked to breast cancer progression and treatment failure.
  • Targeting epigenetic enzymes shows potential as a therapeutic strategy.
  • Combination therapies involving epigenetic agents demonstrate promise.

Conclusions:

  • Targeting epigenetic mechanisms represents a significant frontier in breast cancer therapeutic development.
  • Epigenetic therapies, alone or in combination, offer promising avenues for improving breast cancer treatment outcomes.
Keywords:
AzacitidineBromodomain and extra terminal domain (BET) family inhibitorsDecitabineHistone deacetylase inhibitorsHistone demethylase (HDM) inhibitorsHistone methyltransferase (HMT) inhibitors

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