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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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[Erythema multiforme : target deciphering].

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Updated: Jun 24, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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[Solid tumor lysis syndrome: an entity that should not be neglected].

António Manuel Santos Ferreira1, Agnès Auteri2, Hervé Olivier Zender1,3

  • 1Service de médecine interne, Département de médecine, Réseau hospitalier neuchâtelois, 2300 La Chaux-de-Fonds.

Revue Medicale Suisse
|December 6, 2024
PubMed
Summary

Tumor lysis syndrome is a metabolic emergency from rapid cancer cell breakdown, increasingly seen in solid tumors. Early recognition and management are crucial due to its poor prognosis.

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Area of Science:

  • Oncology
  • Nephrology
  • Metabolic Medicine

Context:

  • Tumor lysis syndrome (TLS) is a critical metabolic emergency arising from extensive cancer cell destruction.
  • While historically linked to hematological malignancies like lymphoma and leukemia, TLS incidence is rising in solid tumors due to advanced oncological treatments.
  • Early identification of TLS is vital given its association with poor patient prognosis.

Purpose:

  • To review the pathophysiology, preventive measures, and treatment strategies for tumor lysis syndrome.
  • To highlight the importance of early recognition and management of TLS in clinical practice.

Summary:

  • This review details the mechanisms of tumor lysis syndrome (TLS), a metabolic crisis caused by widespread cancer cell death.
  • It covers preventative interventions and therapeutic approaches for TLS, emphasizing early detection.
  • A clinical case involving small cell lung carcinoma illustrates TLS in the context of solid tumors.

Impact:

  • Enhances understanding of tumor lysis syndrome (TLS) pathophysiology and clinical presentation.
  • Provides clinicians with essential information on preventing and treating TLS, potentially improving patient outcomes.
  • Contributes to the growing body of knowledge on TLS in solid tumors, informing future oncological treatment strategies.