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Updated: May 24, 2025
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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
6.8K
Plant cell-cycle regulators control the nuclear environment for viral pathogenesis.
Xu Zhang1, Ge Wang1, Peng Zhang1
1College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018, Shandong, China.
Cell Host & Microbe
|March 5, 2025
Summary
Viruses hijack tomato
Area of Science:
- Plant virology
- Molecular plant pathology
- Cell cycle regulation
Background:
- Cell cycle regulators are crucial for viral replication and plant growth.
- The interaction between RETINOBLASTOMA-RELATED 1 (RBR1) and E2F transcription factors in host-virus interactions is not fully understood.
Purpose of the Study:
- To elucidate the mechanisms by which viruses manipulate RBR1-E2F complexes in tomato.
- To understand how this manipulation affects host plant growth and viral propagation.
Main Methods:
- Investigated the interaction between tomato's anaphase-promoting complex/cyclosome (APC/C) activator CDC20 and RBR1.
- Analyzed the role of APC/CCDC20 in regulating RBR1 and cyclin D1 levels.
- Examined viral strategies to repurpose APC/CCDC20 activity.
Main Results:
- Tomato APC/CCDC20 binds RBR1 or depletes cyclin D1, preserving RBR1-E2F complexes.
- Geminivirus and crinivirus manipulate APC/CCDC20 to either degrade RBR1 or block cyclin D1, liberating E2Fs.
- Liberated E2Fs activate viral replication genes (DNA polymerase, HSP70).
- Disruption of RBR1-E2F complexes leads to host growth repression.
Conclusions:
- Viruses exploit the host's APC/CCDC20 to control RBR1-E2F complexes for their own replication.
- This viral strategy disrupts host cell cycle regulation, favoring virus propagation at the expense of plant vitality.
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