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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Solute Delivery Through a Porous-Walled Microtube With Sinusoidal Roughness by Electroosmotic Pumping.

Ajay Kumar¹, Himanshu Gupta¹, Sirshendu De¹

¹Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India.

Electrophoresis

|March 6, 2025

Summary

This study shows how sinusoidal roughness in microchannels affects solute delivery via electroosmotic flow. Optimized roughness parameters can reduce velocity, enhancing solute transport for applications like drug delivery.

Keywords:

drug delivery mass transfer neutral solute porous wall sinusoidal roughness

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Area of Science:

Microfluidics and Transport Phenomena
Biomedical Engineering
Physical Chemistry

Background:

Understanding solute transport in microchannels is crucial for drug delivery and biological systems.
Electroosmotic flow (EOF) is a key mechanism for fluid manipulation in microfluidic devices.
Surface roughness can significantly alter flow dynamics and transport characteristics.

Purpose of the Study:

To investigate the impact of sinusoidal roughness on neutral solute delivery through porous-walled micro-tubes under mixed EOF pumping.
To quantify the effects of various operating conditions, geometries, and fluid properties on solute mass flux.
To explore the novelty of sinusoidal roughness in enhancing solute mass flux delivery.

Main Methods:

Numerical investigation of solute transport in a microtube with sinusoidal wall roughness.
Modeling mixed electroosmotic and pressure-driven flow under a direct current electric field.
Systematic analysis of roughness parameters (amplitude and wavenumber), tube geometry, and fluid properties.

Main Results:

Increased relative roughness amplitude and wavenumber decreased average cross-sectional velocity by up to 31%.
Trans-wall pressure drop was identified as the most dominant parameter influencing solute permeation flux, enhancing it by 16-19%.
Roughness parameters were found to decrease velocity, potentially aiding solute delivery by increasing residence time.

Conclusions:

Sinusoidal roughness significantly impacts solute transport in microfluidic channels.
Tuning roughness parameters and trans-wall pressure can optimize solute delivery for microfluidic applications.
Findings offer design insights for targeted drug delivery systems and understanding biological nutrient transport.