Neurexin-3 is Elevated and Associated with Cognition Status and 4-Hydroxynonenal in Bipolar Disorder
Guguloth Sudhakar1, Hanumanthappa Nandeesha1, Vikas Menon2
1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Background:
Alteration in synaptic plasticity and oxidative stress is involved in the pathogenesis of bipolar disorder (BD).
Purpose:
The objectives of the study were to analyse neurexin-3 and 4-hydroxynonenal (4-HNE) levels in BD and their relation with cognitive scores and severity of the disease.
Methods:
Eighty-four BD patients and 84 healthy volunteers were enrolled. Neurexin-3 and 4-HNE were analysed by enzyme-linked immunosorbent assay (ELISA). Cognitive scores were determined using Addenbrooke's Cognitive Examination III (ACE-III) scores.
Results:
4-HNE (p < .001) and neurexin-3 (p < .001) were higher in BD cases in comparison with controls. 4-HNE was positively related to neurexin-3 (p = .048). Neurexin-3 was related to the total ACE-III score (p = .029), attention (p = .040) and fluency (p = .026) scores in BD cases. When multivariate analysis was done, neurexin-3 was related to ACE-III score in BD (p = .005).
Conclusion:
We conclude that neurexin-3 is increased and associated with 4-HNE and cognitive dysfunction in BD.
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